Fabian Busch was born October 1, 1975, in Berlin. Both his parents are dancers. Although he had no training as an actor, Busch got the leading role in Wolfgang Kohlhaase's film "Inge, April und Mai" ("Inge, April and May") in 1993. He then played significant roles in Matthias X. Oberg's road movie "Unter der Milchstraße" ("Under the Milky Way", 1996), in Hans Christian Schmid's hacker thriller "23" (1998), in Andreas Dresen's "Raus aus der Haut" (1997), and in both the TV mini series "Klemperer – ein Leben in Deutschland" (1999) and "Deutschlandspiel" (2000).

Furthermore, Busch won a nomination for the 2000 German TV awards for his part in the TV movie "Zehn wahnsinnige Tage", directed by Christian Wagner.

Busch then starred in Rainer Kaufmann's film "Kalt ist der Abendhauch" ("Cold Is the Evening Breeze") and became known to a wider audience with his performance in Hendrik Handloegten's coming-of-age film "Liegen lernen" ("Learning to Lie", 2003), an adaptation of Frank Goosen's best-selling novel of the same title. Busch then played in Michael Klier's drama "Farland" and in Cyril Tuschi's comedy "SommerHundeSöhne" ("Slight Changes in Temperature and Mind", both 2004). In 2007, Busch is seen in another comedy as a video store owner facing bankruptcy in Daniel Acht's and Ali Eckert's "Video Kings".

Besides further feature films as an actor like "Finnischer Tango" ("Finnish Tango") by Buket Alakus or "Die Tränen meiner Mutter" ("My Mother's Tears") by Alejandro Cardenas-Amelio Fabian Busch finished his first movie as a director in 2008: the 13-minute-long "Edgar" wins several awards, among them Murnau-Kurzfilmpreis 2009. In the feature "Gegengerade - 20359 St. Pauli", he portrayed a player of German football team FC St. Pauli.

After starring in a slew of TV productions and supporting roles in "Abseitsfalle" (2012) and "Quatsch und die Nasenbärbande" ("Fiddlesticks", 2014), Busch was cast one of the leads in the screen adaptation of the bestselling novel "Er ist wieder da" ("Look Who's Back", 2015).