From 2000 to 2003, Ketel Weber studied acting at the Europäische Theaterinstitut Berlin. He went on to play supporting roles in feature films like "Die blaue Grenze" ("A Quiet Love"; 2005) and "Lange Nacht - Der Anfang der Nacht ist das Ende der Welt" (2009), and also appeared in TV productions like "Wolff - Kampf im Revier" (2012).

He got his first leading role in the futuristic thriller "Dr. Ketel", which premiered at the 2011 Oldenburg Film Festival and was theatrically released in summer 2013. In the film, Weber plays an underground physician who treats patients without health insurance in a derelict Berlin and who is targeted by the authorities.