Maike Mia Höhne was born in Hannover in 1971. From 1994 until 1999, she studied visual communication and film at the Hochschule für Bildende Künste (HfbK) in Hamburg, the Escuela de Bellas Artes in Havanna, and the Escuela International de Cine y Television in San Antonio de los Baños, Cuba. She later also enrolled in a post-graduate film class at the HfbK.

From 2001 on, Maike Mia Höhne worked as a freelance, curator, author, photographer, producer and director. She completed several experimental shorts, which were distributed by Arsenal Berlin and the Hamburg Short film Agency. In addition to her own artistic output, she frequently hosted academic talks on film and media. In 2007, Maike Mia Höhne became curator of the section Berlinale Shorts at the IFF Berlin. Moreover, she taught classes at the Hamburg Media School and the HfbK.

As writer-director, Maike Mia Höhne made her first feature-length narrative fiction film with "3/4". The intimate portrait of a couple coping with the unfulfilled wish to have a child together screened at the 2014 Filmfest Hamburg and was released in Germany in summer 2016.