Esmée Liliane Amuat was born on March 7, 1989 in Zurich, Switzerland. From 2008 to 2012 she completed her acting studies at the Max Reinhardt Seminar in Vienna. During her studies she performed at the Schauspielhaus Zurich and the Wiener Festwochen. From 2012 to 2015 she was a member of the ensemble of the Vienna Burgtheater, where she was awarded the Young Talent Prize in 2014. In 2015 she joined the ensemble of Theater Basel from where she moved on to the  Residenztheater Munich in 2019.  

In addition to her theater work, Liliane Amuat has also appeared in film productions. She made her film debut in 2013 with a leading role in the Swiss military comedy "Achtung, fertig, WK!" ("Ready, Steady, Ommm!")  as the daughter of a commander whose boyfriend is trying to avoid military service. She then had supporting roles in the romantic comedy "Miss Sixty" (2014) alongside Iris Berben and in Marie Kreutzer's social comedy "Gruber geht" ("Gruber Is Leaving", AT 2014).  

For her title role in "Skizzen von Lou" ("Sketches of Lou", CH 2015), in which she portrayed a free-spirited nomad who falls in love and must suddenly allow emotional intimacy, Amuat was nominated for Best Actress at the 2017 Swiss Film Awards. She also received a nomination for Best Emerging Actress at the Max Ophüls Prize Film Festival in 2017.  

In the TV comedy "Lotto" (CH 2017), she played a young woman who pretends to her seriously ill father that he has finally won the lottery. For this role, Amuat was awarded the Swiss Television Film Prize for Best Supporting Actress. In theater, Amuat received the Kurt Meisel Prize in 2020 for her work at the Residenztheater in Munich. In the same year, she was awarded the Bavarian Art Promotion Prize in the performing arts category.
 
Alongside Henriette Confurius, Amuat played one of the two lead roles in "Das Mädchen und die Spinne " ("The Girl and the Spider", CH 2021), which won the Best Direction award (Ramon and Silvan Zürcher) and the Fipresci Award at the 2021 Berlinale.  

Amuat was next seen on the big screen in 2023, starring in the relationship drama "Südsee" ("Salty Water"), which premiered at the Munich Film Festival, and in the film adaptation of "Die Mittagsfrau" ("Blind at Heart", DE/CH/LU), portraying a young woman from the provinces who gets caught up in a wild whirlwind of parties and drug excesses in 1920s Berlin, often referred to as the "Golden Twenties".